Premature Neural Progenitor Cell Differentiation Into Astrocytes in Retinoic Acid-Induced Spina Bifida Rat Model

Premature Neural Progenitor Cell Differentiation Into Astrocytes in Retinoic Acid-Induced Spina Bifida Rat Model

During embryonic spinal cord development, neural progenitor cells (NPCs) generate three major cell lines: neurons, oligodendrocytes, and astrocytes at precise times and locations within the spinal cord. Recent studies demonstrate early astrogenesis in animal models of spina bifida, which may play a...

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Bibliographic Details
Main Authors: Marc Oria, Bedika Pathak, Zhen Li, Kenan Bakri, Kara Gouwens, Maria Florencia Varela, Kristin Lampe, Kendall P. Murphy, Chia-Ying Lin, Jose L. Peiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neural tube defect (NTD)
spina bifida (SB)
neural progenitor cell (NPC)
astrogenesis
Pax6
Olig2
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.888351/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.888351/full

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