Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells.

Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells.

The AMP-activated protein kinase (AMPK) signaling system plays a key role in cellular stress by repressing the inflammatory responses induced by the nuclear factor-kappa B (NF-κB) system. Previous studies suggest that the anti-inflammatory role of AMPK involves activation by adenine, but the mechani...

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Bibliographic Details
Main Authors: Yi-Fang Cheng, Guang-Huar Young, Jiun-Tsai Lin, Hyun-Hwa Jang, Chin-Chen Chen, Jing-Yi Nong, Po-Ku Chen, Cheng-Yi Kuo, Shao-Hsuan Kao, Yao-Jen Liang, Han-Min Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4636334?pdf=render

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http://europepmc.org/articles/PMC4636334?pdf=render

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