Design and characterization of a heterobifunctional degrader of KEAP1

Design and characterization of a heterobifunctional degrader of KEAP1

The Kelch-like ECH-associated protein 1 (KEAP1) - nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway senses reactive oxygen species and regulates cellular oxidative stress. Inhibiting KEAP1 to activate the NRF2 antioxidant response has been proposed as a promising strategy to treat...

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Bibliographic Details
Main Authors: Hao Chen, Nghi H. Nguyen, Charlene M. Magtoto, Simon A. Cobbold, Grace M. Bidgood, Lizeth G. Meza Guzman, Lachlan W. Richardson, Jason Corbin, Amanda E. Au, Bernhard C. Lechtenberg, Rebecca Feltham, Kate D. Sutherland, Christoph Grohmann, Sandra E. Nicholson, Brad E. Sleebs
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Redox Biology
Subjects:
PROTAC
KEAP1-NRF2 pathway
Antioxidant
ROS
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172200324X

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http://www.sciencedirect.com/science/article/pii/S221323172200324X

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