Ultra-low-coverage genome-wide association study—insights into gestational age using 17,844 embryo samples with preimplantation genetic testing

Ultra-low-coverage genome-wide association study—insights into gestational age using 17,844 embryo samples with preimplantation genetic testing

Abstract Background Very low-coverage (0.1 to 1×) whole genome sequencing (WGS) has become a promising and affordable approach to discover genomic variants of human populations for genome-wide association study (GWAS). To support genetic screening using preimplantation genetic testing (PGT) in a lar...

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Bibliographic Details
Main Authors: Shumin Li, Bin Yan, Thomas K. T. Li, Jianliang Lu, Yifan Gu, Yueqiu Tan, Fei Gong, Tak-Wah Lam, Pingyuan Xie, Yuexuan Wang, Ge Lin, Ruibang Luo
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Genome Medicine
Subjects:
Ultra-low-coverage whole genome sequencing
Imputation
Single-nucleotide polymorphisms
Genome-wide association study
Gestational age
Preterm birth
Online Access:https://doi.org/10.1186/s13073-023-01158-7

Internet

https://doi.org/10.1186/s13073-023-01158-7

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