Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury

Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury

Abstract Background Neuroinflammation and mitochondrial dysfunction play crucial roles in retinal ischemia and reperfusion (IR) injury. Recent studies have identified mitochondrial function as a promising target for immunomodulation. Empagliflozin (EMPA), an anti-diabetic drug, has exhibited great p...

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Bibliographic Details
Main Authors: Zhenlan Yang, Yidan Liu, Xuhao Chen, Shaofen Huang, Yangyang Li, Guitong Ye, Xu Cao, Wenru Su, Yehong Zhuo
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Neuroinflammation
Subjects:
Retinal ischemia and reperfusion injury
Neuroinflammation
Empagliflozin
Mitofusin 1
Optic atrophy 1
Online Access:https://doi.org/10.1186/s12974-023-02982-9

Internet

https://doi.org/10.1186/s12974-023-02982-9

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