First-in-human pilot trial of combined intracoronary and intravenous mesenchymal stem cell therapy in acute myocardial infarction

First-in-human pilot trial of combined intracoronary and intravenous mesenchymal stem cell therapy in acute myocardial infarction

BackgroundAcute ST-elevation myocardial infarction (STEMI) elicits a robust cardiomyocyte death and inflammatory responses despite timely revascularization.ObjectivesThis phase 1, open-label, single-arm, first-in-human study aimed to assess the safety and efficacy of combined intracoronary (IC) and...

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Main Authors: Lien-Cheng Hsiao, Yen-Nien Lin, Woei-Cherng Shyu, Ming Ho, Chiung-Ray Lu, Shih-Sheng Chang, Yu-Chen Wang, Jan-Yow Chen, Shang-Yeh Lu, Mei-Yao Wu, Keng-Yuan Li, Yu-Kai Lin, Wen-Yih I. Tseng, Mao-Yuan Su, Chin-Ting Hsu, Cheng-Kang Tsai, Lu-Ting Chiu, Chien-Lin Chen, Cheng-Li Lin, Kai-Chieh Hu, Der-Yang Cho, Chang-Hai Tsai, Kuan-Cheng Chang, Long-Bin Jeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
intracoronary
intravenous
umbilical mesenchymal stem cell
acute myocardial infarction
human pilot trial
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.961920/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.961920/full

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