KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes

KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes

Objective: Increasing plasma levels and activity of dipeptidyl peptidase-4 (DPP4 or CD26) are associated with rapid progression of metabolic syndrome to overt type 2 diabetes mellitus (T2DM). While DPP4 inhibitors are increasingly used as anti-hyperglycemic agents, the reason for the increase in pla...

Full description

Bibliographic Details
Main Authors: Titli Nargis, Krishna Kumar, Amrit Raj Ghosh, Amit Sharma, Dipayan Rudra, Debrup Sen, Saikat Chakrabarti, Satinath Mukhopadhyay, Dipyaman Ganguly, Partha Chakrabarti
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Molecular Metabolism
Subjects:
DPP4
KLK5
PBMC
T2DM
Th17 cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817305410

Internet

http://www.sciencedirect.com/science/article/pii/S2212877817305410

Similar Items