Hepatitis C virus hypervariable region 1 antibodies interrupt E2-SR-B1 interaction to suppress viral infection

Hepatitis C virus hypervariable region 1 antibodies interrupt E2-SR-B1 interaction to suppress viral infection

Summary: Whether hypervariable region 1 (HVR1)-targeting antibodies elicited during natural hepatitis C virus (HCV) infection contribute to virus clearance and what is the mechanism underlying remain unclear. Here, we demonstrated that treatment of HCV-infected hepatoma Huh7.5 cells with the IgGs pu...

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Bibliographic Details
Main Authors: Kai Deng, Qing Zhou, Zhanxue Xu, Yuhao Yang, Xi Liu, Chunna Li, Mingxiao Chen, Zhenzhen Zhang, Haihang Chen, Ling Ma, Muhammad Ikram Anwar, Changlong Zheng, Liang Rong, Mingxing Huang, Jinyu Xia, Yuanping Zhou, Yi-Ping Li
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Immunology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223004984

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http://www.sciencedirect.com/science/article/pii/S2589004223004984

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