Efficient delivery of the lncRNA LEF1-AS1 through the antibody LAIR-1 (CD305)-modified Zn-Adenine targets articular inflammation to enhance the treatment of rheumatoid arthritis

Efficient delivery of the lncRNA LEF1-AS1 through the antibody LAIR-1 (CD305)-modified Zn-Adenine targets articular inflammation to enhance the treatment of rheumatoid arthritis

Abstract Backgrounds Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovial hyperplasia. Maintaining a balance between the proliferation and apoptosis of rheumatoid arthritis synovial fibroblasts (RASFs) is crucial for preventing the erosion of bone and cart...

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Bibliographic Details
Main Authors: Xiaonan Zhang, Xiaoyu He, Ming Zhang, Tianyu Wu, Xiaojie Liu, Yan Zhang, Zhuobei Xie, Saisai Liu, Tian Xia, Yuanyuan Wang, Fang Wei, Hongtao Wang, Changhao Xie
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Arthritis Research & Therapy
Subjects:
Nanomedicine
LncRNA LEF1-AS1
miR-30-5p
PIK3R2
Rheumatoid arthritis
Synovial fibroblasts
Online Access:https://doi.org/10.1186/s13075-023-03226-0

Internet

https://doi.org/10.1186/s13075-023-03226-0

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