Efficient delivery of the lncRNA LEF1-AS1 through the antibody LAIR-1 (CD305)-modified Zn-Adenine targets articular inflammation to enhance the treatment of rheumatoid arthritis
Abstract Backgrounds Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovial hyperplasia. Maintaining a balance between the proliferation and apoptosis of rheumatoid arthritis synovial fibroblasts (RASFs) is crucial for preventing the erosion of bone and cart...
Main Authors: | Xiaonan Zhang, Xiaoyu He, Ming Zhang, Tianyu Wu, Xiaojie Liu, Yan Zhang, Zhuobei Xie, Saisai Liu, Tian Xia, Yuanyuan Wang, Fang Wei, Hongtao Wang, Changhao Xie |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-12-01
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Series: | Arthritis Research & Therapy |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13075-023-03226-0 |
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