AMPK-Dependent Mechanisms but Not Hypothalamic Lipid Signaling Mediates GH-Secretory Responses to GHRH and Ghrelin

AMPK-Dependent Mechanisms but Not Hypothalamic Lipid Signaling Mediates GH-Secretory Responses to GHRH and Ghrelin

GH (growth hormone) secretion/action is modulated by alterations in energy homeostasis, such as malnutrition and obesity. Recent data have uncovered the mechanism by which hypothalamic neurons sense nutrient bioavailability, with a relevant contribution of AMPK (AMP-activated protein kinase) and mTO...

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Bibliographic Details
Main Authors: María J. Vázquez, Marta G. Novelle, Francisca Rodríguez-Pacheco, Ricardo Lage, Luis Varela, Miguel López, Leonor Pinilla, Manuel Tena-Sempere, Carlos Diéguez
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
AMPK
GH
GHRH
ghrelin
hypothalamic signaling
Online Access:https://www.mdpi.com/2073-4409/9/9/1940

Internet

https://www.mdpi.com/2073-4409/9/9/1940

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