Harnessing Pentameric Scaffold of Cholera Toxin B (CTB) for Design of Subvirion Recombinant Dengue Virus Vaccine

Harnessing Pentameric Scaffold of Cholera Toxin B (CTB) for Design of Subvirion Recombinant Dengue Virus Vaccine

Dengue virus is an enveloped virus with an icosahedral assembly of envelope proteins (E). The E proteins are arranged as a head-to-tail homodimer, and domain III (EDIII) is placed at the edge of the dimer, converging to a pentamer interface. For a structure-based approach, cholera toxin B (CTB) was...

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Bibliographic Details
Main Authors: Jemin Sung, Yucheol Cheong, Young-Seok Kim, Jina Ahn, Myung Hyun Sohn, Sanguine Byun, Baik-Lin Seong
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Vaccines
Subjects:
dengue
cholera toxin B
recombinant protein
protein folding
Online Access:https://www.mdpi.com/2076-393X/12/1/92

Internet

https://www.mdpi.com/2076-393X/12/1/92

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