Developmental and behavioral toxicity assessment of opicapone in zebrafish embryos

Developmental and behavioral toxicity assessment of opicapone in zebrafish embryos

The use of clinical psychoactive drugs often poses unpredictable threats to fetal development. Catechol-O-methyltransferase (COMT) is a key enzyme that regulates dopamine metabolism and a promising target for modulation of cognitive functions. Opicapone, a newly effective third-generation peripheral...

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Bibliographic Details
Main Authors: Zhengkang Su, Kaiyu Guan, Yunbin Liu, Hai Zhang, Zhengwei Huang, Miaomiao Zheng, Ya Zhu, He Zhang, Weihong Song, Xi Li
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
COMT inhibitor
Opicapone
Dopamine metabolism
Zebrafish larvae
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322011800

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http://www.sciencedirect.com/science/article/pii/S0147651322011800

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