The Lateral Metalation of Isoxazolo[3,4-<i>d</i>]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors

The Lateral Metalation of Isoxazolo[3,4-<i>d</i>]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors

Isoxazolo[3,4-<i>d</i>] pyridazinones ([3,4-<i>d</i>]s) were previously shown to have selective positive modulation at the metabotropic glutamate receptor (mGluR) Subtypes 2 and 4, with no functional cross-reactivity at mGluR<sub>1a</sub>, mGluR<sub>5</su...

Full description

Bibliographic Details
Main Authors: Christina A. Gates, Donald S. Backos, Philip Reigan, Nicholas R. Natale
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Molecules
Subjects:
isoxazole
lateral metalation
metabotropic glutamate receptor
Online Access:https://www.mdpi.com/1420-3049/28/19/6800

Internet

https://www.mdpi.com/1420-3049/28/19/6800

Similar Items