UHRF1 downmodulation enhances antitumor effects of histone deacetylase inhibitors in retinoblastoma by augmenting oxidative stress‐mediated apoptosis

UHRF1 downmodulation enhances antitumor effects of histone deacetylase inhibitors in retinoblastoma by augmenting oxidative stress‐mediated apoptosis

Identification of new genetic pathways or molecular targets that sensitize cancer cells to chemotherapeutic drugs may improve the efficacy of current chemotherapy. Here, we report that downmodulation of UHRF1 (ubiquitin‐like with PHD and RING finger domains 1) in retinoblastoma (RB) cells increases...

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Bibliographic Details
Main Authors: Jong Kyong Kim, Guangyan Kan, Yu Mao, Zhixuan Wu, Xionghong Tan, Heng He, Chunsik Lee
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Molecular Oncology
Subjects:
chemotherapy
drug sensitivity
HDAC inhibitors
retinoblastoma
UHRF1
Online Access:https://doi.org/10.1002/1878-0261.12607

Internet

https://doi.org/10.1002/1878-0261.12607

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