Reduced <i>Ribose-5-Phosphate Isomerase A-1</i> Expression in Specific Neurons and Time Points Promotes Longevity in <i>Caenorhabditis elegans</i>

Reduced <i>Ribose-5-Phosphate Isomerase A-1</i> Expression in Specific Neurons and Time Points Promotes Longevity in <i>Caenorhabditis elegans</i>

Deregulation of redox homeostasis is often associated with an accelerated aging process. Ribose-5-phosphate isomerase A (RPIA) mediates redox homeostasis in the pentose phosphate pathway (PPP). Our previous study demonstrated that <i>Rpi</i> knockdown boosts the healthspan in <i>Dr...

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Bibliographic Details
Main Authors: Wen-Chi Shen, Chiou-Hwa Yuh, Yu-Ting Lu, Yen-Hung Lin, Tsui-Ting Ching, Chao-Yung Wang, Horng-Dar Wang
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antioxidants
Subjects:
<i>ribose-5-phosphate isomerase A</i> (RPIA)
pentose phosphate pathway (PPP)
autophagy
AMP activated protein kinase (AMPK)
target of rapamycin (TOR)
lifespan
Online Access:https://www.mdpi.com/2076-3921/12/1/124

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https://www.mdpi.com/2076-3921/12/1/124

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