Absorption, metabolism, and excretion of [14C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers

Absorption, metabolism, and excretion of [14C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers

Abstract Dersimelagon (formerly MT‐7117) is a novel, orally administered nonpeptide small molecule selective agonist for melanocortin 1 receptor currently being investigated for the treatment of erythropoietic protoporphyria, X‐linked protoporphyria, and diffuse cutaneous systemic sclerosis (dcSSc)....

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Bibliographic Details
Main Authors: Minoru Tsuda, Kei Ogawa, Tadashi Endou, Takahiro Goto, Yuko Ogasawara, Akihito Ogasawara
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Pharmacology Research & Perspectives
Subjects:
absorption
dersimelagon
erythropoietic protoporphyria
excretion
metabolism
X‐linked protoporphyria
Online Access:https://doi.org/10.1002/prp2.1084

Internet

https://doi.org/10.1002/prp2.1084

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