Sub-Acute Oral Toxicity of a Novel Derivative of Agomelatine in Rats in a Sex-Dependent Manner

Sub-Acute Oral Toxicity of a Novel Derivative of Agomelatine in Rats in a Sex-Dependent Manner

Agomelatine (AGO) is a new type of antidepressant with demonstrated antidepressant effects and a unique modulating circadian rhythm action. However, AGO has hepatotoxicity, which limits its clinical application. In order to develop new drugs that cause less liver injury than AGO, a series of derivat...

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Bibliographic Details
Main Authors: Qiushi Yang, Xuelin Zhou, Jingyi Li, Yi Ma, Li Lu, Jie Xiong, Pingxiang Xu, Yuhang Li, Yi Chen, Wei Gu, Ming Xue, Zengliang Jin, Xiaorong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
antidepressant
agomelatine
derivative
toxicity
GW117
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00242/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00242/full

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