Compartmentalized control of Cdk1 drives mitotic spindle assembly

Summary: During cell division, dramatic microtubular rearrangements driven by cyclin B-cdk1 (Cdk1) kinase activity mark the onset of mitosis leading to dismantling of the interphase microtubular cytoskeleton and assembly of the mitotic spindle. During interphase, Cdk1 accumulates in an inactive stat...

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Bibliographic Details
Main Authors: Angela Flavia Serpico, Francesco Febbraro, Caterina Pisauro, Domenico Grieco
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722000171