The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice

The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice

Abstract Objective We investigated the suppressive effect of siRNA-mediated co-inhibition of PD-1 and CTLA-4 expression on H22 hepatomas in mice. Methods Murine H22 cells were cultured in vivo in ICR mice. An allograft tumor model was also established in another ICR mouse group. The tumor-bearing mi...

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Bibliographic Details
Main Authors: Leilei Liang, Keli Ge, Fengying Zhang, Yinlin Ge
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Cellular & Molecular Biology Letters
Subjects:
PD-1
CTLA -4
H22
siRNA
Immune
IFN-γ
Online Access:http://link.springer.com/article/10.1186/s11658-018-0122-0

Internet

http://link.springer.com/article/10.1186/s11658-018-0122-0

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