High Recovery Chromatographic Purification of mRNA at Room Temperature and Neutral pH

High Recovery Chromatographic Purification of mRNA at Room Temperature and Neutral pH

Messenger RNA (mRNA) is becoming an increasingly important therapeutic modality due to its potential for fast development and platform production. New emerging RNA modalities, such as circular RNA, drive the need for the development of non-affinity purification approaches. Recently, the highly effic...

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Bibliographic Details
Main Authors: Rok Miklavčič, Polona Megušar, Špela Meta Kodermac, Blaž Bakalar, Darko Dolenc, Rok Sekirnik, Aleš Štrancar, Urh Černigoj
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
mRNA stability
nucleic acids separation
liquid chromatography
chromatographic monoliths
weak anion-exchanger
preparative chromatography
Online Access:https://www.mdpi.com/1422-0067/24/18/14267

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https://www.mdpi.com/1422-0067/24/18/14267

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