Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer

Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer

ASH1L is a member of the Trithorax-group protein and acts as a histone methyltransferase for gene transcription activation. It is known that ASH1L modulates H3K4me3 and H3K36me2/3 at its gene targets, but its specific mechanism of histone recognition is insufficiently understood. In this study, we f...

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Bibliographic Details
Main Authors: Miaomiao Yu, Yanjie Jia, Zhanchuan Ma, Donglei Ji, Chunyu Wang, Yingying Liang, Qiang Zhang, Huanfa Yi, Lei Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
ASH1L
PHD finger
histone methylation
H3K4me2
prostate cancer
cell cycle and apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.906807/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.906807/full

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