Rapid Reversible Osmoregulation of Cytoplasmic Biomolecular Condensates of Human Interferon-α-Induced Antiviral MxA GTPase

Rapid Reversible Osmoregulation of Cytoplasmic Biomolecular Condensates of Human Interferon-α-Induced Antiviral MxA GTPase

We previously discovered that exogenously expressed GFP-tagged cytoplasmic human myxovirus resistance protein (MxA), a major antiviral effector of Type I and III interferons (IFNs) against several RNA- and DNA-containing viruses, existed in the cytoplasm in phase-separated membraneless biomolecular...

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Bibliographic Details
Main Authors: Pravin B. Sehgal, Huijuan Yuan, Ye Jin
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
liquid-liquid phase separation (LLPS)
biomolecular condensates
membraneless organelles (MLOs)
endogenous interferon-α-induced human myxovirus resistance protein (MxA)
osmoregulation
hypotonic stress
Online Access:https://www.mdpi.com/1422-0067/23/21/12739

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https://www.mdpi.com/1422-0067/23/21/12739

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