Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein

Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein

Neutralizing monoclonal antibodies (mAbs) against highly pathogenic coronaviruses represent promising candidates for clinical intervention. Here, we isolated a potent neutralizing monoclonal antibody, MERS-S41, from a yeast displayed scFv library using the S protein as a bait. To uncover the neutral...

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Bibliographic Details
Main Authors: Shuyuan Zhang, Wenxv Jia, Jianwei Zeng, Mingxi Li, Ziyi Wang, Haixia Zhou, Linqi Zhang, Xinquan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Microbiology
Subjects:
neutralizing antibody
MERS-CoV
spike glycoprotein
cryo-EM structures
neutralization mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.988298/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.988298/full

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