Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance

Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance

Abstract Background Ketone bodies (KBs) are an alternative energy supply for brain functions when glucose is limited. The most abundant ketone metabolite, 3-β-hydroxybutyrate (BOHBUT), has been suggested to prevent or delay cognitive impairment, but the evidence remains unclear. We triangulated obse...

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Bibliographic Details
Main Authors: Wichanon Sae-jie, Suangsuda Supasai, Mika Kivimaki, Jackie F. Price, Andrew Wong, Meena Kumari, Jorgen Engmann, Tina Shah, Amand F. Schmidt, Tom R. Gaunt, Aroon Hingorani, Pimphen Charoen, on behalf of the UCLEB Consortium
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Medicine
Subjects:
Ketone bodies
Cognitive performance
Alzheimer’s disease
Mendelian randomization
Online Access:https://doi.org/10.1186/s12916-023-03047-7

Internet

https://doi.org/10.1186/s12916-023-03047-7

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