Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced Parkinson’s disease in rats

Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced Parkinson’s disease in rats

Sodium-glucose co-transporter 2 (SGLT 2) inhibitors are a relatively new antidiabetic drug with antioxidant and anti-inflammatory properties. Therefore, this study aimed to investigate whether SGLT 2 inhibitors have a neuroprotective effect in PD. Twenty-four Wistar rats were randomized into four gr...

Full description

Bibliographic Details
Main Authors: Sanaa Ahmed, Mahmoud M. El-Sayed, Mohamed A. Kandeil, Marwa M. Khalaf
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Saudi Pharmaceutical Journal
Subjects:
Parkinsonism
Neuroprotection
SGLT-2 inhibitors
Neurodegeneration
Rotenone
α-synuclein
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016422000640

Internet

http://www.sciencedirect.com/science/article/pii/S1319016422000640

Similar Items