Proteomics of the dentate gyrus reveals semantic dementia specific molecular pathology

Proteomics of the dentate gyrus reveals semantic dementia specific molecular pathology

Abstract Semantic dementia (SD) is a clinical subtype of frontotemporal dementia consistent with the neuropathological diagnosis frontotemporal lobar degeneration (FTLD) TDP type C, with characteristic round TDP-43 protein inclusions in the dentate gyrus. Despite this striking clinicopathological co...

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Bibliographic Details
Main Authors: Merel O. Mol, Suzanne S. M. Miedema, Shamiram Melhem, Ka Wan Li, Frank Koopmans, Harro Seelaar, Kurt Gottmann, Volkmar Lessmann, Netherlands Brain Bank, August B. Smit, John C. van Swieten, Jeroen G. J. van Rooij
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Acta Neuropathologica Communications
Subjects:
Semantic dementia
Frontotemporal dementia
Frontotemporal lobar degeneration
TDP-43
Mass spectrometry
Proteomics
Online Access:https://doi.org/10.1186/s40478-022-01499-1

Internet

https://doi.org/10.1186/s40478-022-01499-1

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