Public T-Cell Receptors (TCRs) Revisited by Analysis of the Magnitude of Identical and Highly-Similar TCRs in Virus-Specific T-Cell Repertoires of Healthy Individuals

Public T-Cell Receptors (TCRs) Revisited by Analysis of the Magnitude of Identical and Highly-Similar TCRs in Virus-Specific T-Cell Repertoires of Healthy Individuals

Since multiple different T-cell receptor (TCR) sequences can bind to the same peptide-MHC combination and the number of TCR-sequences that can theoretically be generated even exceeds the number of T cells in a human body, the likelihood that many public identical (PUB-I) TCR-sequences frequently con...

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Bibliographic Details
Main Authors: Wesley Huisman, Lois Hageman, Didier A. T. Leboux, Alexandra Khmelevskaya, Grigory A. Efimov, Marthe C. J. Roex, Derk Amsen, J. H. Frederik Falkenburg, Inge Jedema
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
virus-specific T cell responses
TCR - T cell receptor
public T cell receptors
computational analysis
CDR3 amino acid motifs
memory T cells (Tmem)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.851868/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.851868/full

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