Design of Protegrin-1 Analogs with Improved Antibacterial Selectivity

Design of Protegrin-1 Analogs with Improved Antibacterial Selectivity

Protegrin-1 (PG-1) is a cationic β-hairpin pore-forming antimicrobial peptide having a membranolytic mechanism of action. It possesses in vitro a potent antimicrobial activity against a panel of clinically relevant MDR ESKAPE pathogens. However, its extremely high hemolytic activity and cytotoxicity...

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Bibliographic Details
Main Authors: Ilia A. Bolosov, Pavel V. Panteleev, Sergei V. Sychev, Veronika A. Khokhlova, Victoria N. Safronova, Ilia Yu. Toropygin, Tatiana I. Kombarova, Olga V. Korobova, Eugenia S. Pereskokova, Alexander I. Borzilov, Tatiana V. Ovchinnikova, Sergey V. Balandin
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceutics
Subjects:
antimicrobial peptide
protegrin-1
oligomerization
cathelicidin
therapeutic index
Online Access:https://www.mdpi.com/1999-4923/15/8/2047

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https://www.mdpi.com/1999-4923/15/8/2047

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