Overproduction of hydrogen sulfide, generated by cystathionine β-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome

Overproduction of hydrogen sulfide, generated by cystathionine β-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome

Using a novel rat model of Down syndrome (DS), the functional role of the cystathionine-β-synthase (CBS)/hydrogen sulfide (H2S) pathway was investigated on the pathogenesis of brain wave pattern alterations and neurobehavioral dysfunction. Increased expression of CBS and subsequent overproduction of...

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Bibliographic Details
Main Authors: Theodora Panagaki, Laura Lozano-Montes, Lucia Janickova, Karim Zuhra, Marcell P. Szabo, Tomas Majtan, Gregor Rainer, Damien Maréchal, Yann Herault, Csaba Szabo
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Redox Biology
Subjects:
Metabolism
Neurotoxicity
Gamma waves
Gasotransmitters
Trisomy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000052

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http://www.sciencedirect.com/science/article/pii/S2213231722000052

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