Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs
Snail2 is a repressor of E-cadherin during carcinogenesis; however, the specific mechanisms involved in this process remain largely unknown. Here, we determined that Snail2 was highly increased during TGF-β-induced EMT process in lung cells. H3K9 methylation was up-regulated and H3K4/H3K56 acetylati...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Cell Adhesion & Migration |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19336918.2019.1638689 |
| _version_ | 1818284857101385728 |
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| author | Yue Hu Yayuan Zheng Mingrui Dai Jiaxin Wu Bin Yu Haihong Zhang Wei Kong Hui Wu Xianghui Yu |
| author_facet | Yue Hu Yayuan Zheng Mingrui Dai Jiaxin Wu Bin Yu Haihong Zhang Wei Kong Hui Wu Xianghui Yu |
| author_sort | Yue Hu |
| collection | DOAJ |
| description | Snail2 is a repressor of E-cadherin during carcinogenesis; however, the specific mechanisms involved in this process remain largely unknown. Here, we determined that Snail2 was highly increased during TGF-β-induced EMT process in lung cells. H3K9 methylation was up-regulated and H3K4/H3K56 acetylation were down-regulated at the E-cadherin promoter. Snail2 interacted with G9a and HDACs to exert suppression of E-cadherin transcription. Overexpression of Snail2 enhanced the migration and invasion ability, whereas G9a and HDACs inhibition significantly reversed this effect. Our study demonstrated the importance of G9a- and HDACs-mediated regulation during Snail2-induced E-cadherin repression and metastasis during LC progression. |
| first_indexed | 2024-12-13T00:59:28Z |
| format | Article |
| id | doaj.art-8c3aee3c5d6b4c7b8369afaa30bf4f96 |
| institution | Directory Open Access Journal |
| issn | 1933-6918 1933-6926 |
| language | English |
| last_indexed | 2024-12-13T00:59:28Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cell Adhesion & Migration |
| spelling | doaj.art-8c3aee3c5d6b4c7b8369afaa30bf4f962022-12-22T00:04:43ZengTaylor & Francis GroupCell Adhesion & Migration1933-69181933-69262019-01-0113128429110.1080/19336918.2019.16386891638689Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACsYue Hu0Yayuan Zheng1Mingrui Dai2Jiaxin Wu3Bin Yu4Haihong Zhang5Wei Kong6Hui Wu7Xianghui Yu8Jilin UniversityJilin UniversityJilin UniversityJilin UniversityJilin UniversityJilin UniversityJilin UniversityJilin UniversityJilin UniversitySnail2 is a repressor of E-cadherin during carcinogenesis; however, the specific mechanisms involved in this process remain largely unknown. Here, we determined that Snail2 was highly increased during TGF-β-induced EMT process in lung cells. H3K9 methylation was up-regulated and H3K4/H3K56 acetylation were down-regulated at the E-cadherin promoter. Snail2 interacted with G9a and HDACs to exert suppression of E-cadherin transcription. Overexpression of Snail2 enhanced the migration and invasion ability, whereas G9a and HDACs inhibition significantly reversed this effect. Our study demonstrated the importance of G9a- and HDACs-mediated regulation during Snail2-induced E-cadherin repression and metastasis during LC progression.http://dx.doi.org/10.1080/19336918.2019.1638689snail2g9ahdacsepithelial-mesenchymal transitionmetastasislung carcinoma |
| spellingShingle | Yue Hu Yayuan Zheng Mingrui Dai Jiaxin Wu Bin Yu Haihong Zhang Wei Kong Hui Wu Xianghui Yu Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs Cell Adhesion & Migration snail2 g9a hdacs epithelial-mesenchymal transition metastasis lung carcinoma |
| title | Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs |
| title_full | Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs |
| title_fullStr | Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs |
| title_full_unstemmed | Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs |
| title_short | Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs |
| title_sort | snail2 induced e cadherin suppression and metastasis in lung carcinoma facilitated by g9a and hdacs |
| topic | snail2 g9a hdacs epithelial-mesenchymal transition metastasis lung carcinoma |
| url | http://dx.doi.org/10.1080/19336918.2019.1638689 |
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