Hypoxia‐inducible factor‐1α contributes to the proliferation of cholesteatoma keratinocytes through regulating endothelin converting enzyme 1 expression

Hypoxia‐inducible factor‐1α contributes to the proliferation of cholesteatoma keratinocytes through regulating endothelin converting enzyme 1 expression

Abstract Objective Cholesteatoma is a hyperproliferative, pseudoneoplastic lesion of the middle ear characterized by aggressive growth and bone destruction. Hypoxia‐inducible factor‐1α (HIF‐1α, also known as HIF1A) is a key transcription factor that enters the nucleus and upregulates many genes invo...

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Bibliographic Details
Main Authors: Nie Chen, Lei Xu, Zhi Bi, Jian Wu
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Laryngoscope Investigative Otolaryngology
Subjects:
cholesteatoma keratinocytes
ECE1
HIF1A
proliferation
Online Access:https://doi.org/10.1002/lio2.1233

Internet

https://doi.org/10.1002/lio2.1233

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