Hypoxia‐inducible factor‐1α contributes to the proliferation of cholesteatoma keratinocytes through regulating endothelin converting enzyme 1 expression
Abstract Objective Cholesteatoma is a hyperproliferative, pseudoneoplastic lesion of the middle ear characterized by aggressive growth and bone destruction. Hypoxia‐inducible factor‐1α (HIF‐1α, also known as HIF1A) is a key transcription factor that enters the nucleus and upregulates many genes invo...
Main Authors: | Nie Chen, Lei Xu, Zhi Bi, Jian Wu |
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Format: | Article |
Language: | English |
Published: |
Wiley
2024-04-01
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Series: | Laryngoscope Investigative Otolaryngology |
Subjects: | |
Online Access: | https://doi.org/10.1002/lio2.1233 |
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