Myosin Transducer Inter-Strand Communication Is Critical for Normal ATPase Activity and Myofibril Structure

Myosin Transducer Inter-Strand Communication Is Critical for Normal ATPase Activity and Myofibril Structure

The R249Q mutation in human β-cardiac myosin results in hypertrophic cardiomyopathy. We previously showed that inserting this mutation into <i>Drosophila melanogaster</i> indirect flight muscle myosin yields mechanical and locomotory defects. Here, we use transgenic <i>Drosophila&l...

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Bibliographic Details
Main Authors: William A. Kronert, Karen H. Hsu, Aditi Madan, Floyd Sarsoza, Anthony Cammarato, Sanford I. Bernstein
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biology
Subjects:
myosin
<i>Drosophila melanogaster</i>
ATPase
transducer
myofibril
hypertrophic cardiomyopathy
Online Access:https://www.mdpi.com/2079-7737/11/8/1137

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