Efficient generation of GGTA1-null Diannan miniature pigs using TALENs combined with somatic cell nuclear transfer

Efficient generation of GGTA1-null Diannan miniature pigs using TALENs combined with somatic cell nuclear transfer

Abstract Background α1,3-Galactosyltransferase (GGTA1) is essential for the biosynthesis of glycoproteins and therefore a simple and effective target for disrupting the expression of galactose α-1,3-galactose epitopes, which mediate hyperacute rejection (HAR) in xenotransplantation. Miniature pigs a...

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Main Authors: Wenmin Cheng, Heng Zhao, Honghao Yu, Jige Xin, Jia Wang, Luyao Zeng, Zaimei Yuan, Yubo Qing, Honghui Li, Baoyu Jia, Cejun Yang, Youfeng Shen, Lu Zhao, Weirong Pan, Hong-Ye Zhao, Wei Wang, Hong-Jiang Wei
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Reproductive Biology and Endocrinology
Subjects:
GGTA1
TALENs
Cloning
Xenotransplantation
Diannan miniature pigs
Online Access:http://link.springer.com/article/10.1186/s12958-016-0212-7

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http://link.springer.com/article/10.1186/s12958-016-0212-7

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