Biosynthesis of Chiral Amino Alcohols via an Engineered Amine Dehydrogenase in E. coli

Chiral amino alcohols are prevalent synthons in pharmaceuticals and synthetic bioactive compounds. The efficient synthesis of chiral amino alcohols using ammonia as the sole amino donor under mild conditions is highly desired and challenging in organic chemistry and biotechnology. Our previous work...

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Bibliographic Details
Main Authors: Feifei Tong, Zongmin Qin, Hongyue Wang, Yingying Jiang, Junkuan Li, Hui Ming, Ge Qu, Yazhong Xiao, Zhoutong Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.778584/full