Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

Class I histone deacetylase complexes can be activated by inositol phosphates. Here, the authors investigate the stereochemical requirements for activation; use the crystal structure to understand substrate recognition, and suggest an entropically driven mechanism of allostery.

Bibliographic Details
Main Authors: Peter J. Watson, Christopher J. Millard, Andrew M. Riley, Naomi S. Robertson, Lyndsey C. Wright, Himali Y. Godage, Shaun M. Cowley, Andrew G. Jamieson, Barry V. L. Potter, John W. R. Schwabe
Format: Article
Language:English
Published: Nature Portfolio 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11262

Internet

https://doi.org/10.1038/ncomms11262

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