Imaging Calcium in Hippocampal Presynaptic Terminals With a Ratiometric Calcium Sensor in a Novel Transgenic Mouse

Imaging Calcium in Hippocampal Presynaptic Terminals With a Ratiometric Calcium Sensor in a Novel Transgenic Mouse

Genetically encoded calcium indicators (GECIs) have gained widespread use for measurement of neuronal activity but their low expression levels in transgenic mice tend to limit sensitivity. We have developed a transgenic mouse line (SyG37) that expresses a ratiometric calcium sensor, SyGCaMP2-mCherry...

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Bibliographic Details
Main Authors: Ibrahim Al-Osta, Mariusz Mucha, Daniel Pereda, Marta Piqué-Gili, Albert E. Okorocha, Roisin Thomas, Nicholas A. Hartell
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
presynaptic terminals
calcium imaging
transgenic mice
hippocampus
CA1
CA3
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00209/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00209/full

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