t-Bu2SiF-Derivatized D2-Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging

t-Bu2SiF-Derivatized D2-Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging

The synthesis, radiolabeling and in vitro evaluation of new silicon-fluoride acceptor (SiFA) derivatized D2-receptor ligands is reported. The SiFA-technology simplifies the introduction of fluorine-18 into target specific biomolecules for Positron-Emission-Tomography (PET). However, one of the remai...

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Bibliographic Details
Main Authors: Björn Wängler, Klaus Jurkschat, Ralf Schirrmacher, Alexey Kostikov, Christian Rensch, Peter Bartenstein, Klaus Theodor Wanner, Georg Höfner, Thomas Zöller, Carmen Wängler, Ljuba Iovkova-Berends
Format: Article
Language:English
Published: MDPI AG 2011-09-01
Series:Molecules
Subjects:
fluorine
isotopic labeling
positron emission tomography
radiopharmaceuticals
silicon
Online Access:http://www.mdpi.com/1420-3049/16/9/7458/

Internet

http://www.mdpi.com/1420-3049/16/9/7458/

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