A 3D culture system improves the yield of MSCs-derived extracellular vesicles and enhances their therapeutic efficacy for heart repair

A 3D culture system improves the yield of MSCs-derived extracellular vesicles and enhances their therapeutic efficacy for heart repair

Background: Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs), due to their inner functional substances, have shown great value in treating acute myocardial infarction (AMI). However, their clinical application is limited by a low yield. In the present study, we cultured EVs us...

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Bibliographic Details
Main Authors: Ling Sun, Yuan Ji, Boyu Chi, Tingting Xiao, Chenkai Li, Xuejiao Yan, Xu Xiong, Lipeng Mao, Dabei Cai, Ailin Zou, Yu Wang, Le Zhang, Liming Tang, Qingjie Wang
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Extracellular vesicles
Acute myocardial infarction
Mesenchymal stem cells
Three-dimensional culture system
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223003451

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http://www.sciencedirect.com/science/article/pii/S0753332223003451

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