Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses.

Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses.

Understanding the zoonotic risks posed by bat coronaviruses (CoVs) is critical for pandemic preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) bearing spikes from divergent bat CoVs to investigate their cell entry mechanisms. Unexpectedly, the successful recovery of...

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Bibliographic Details
Main Authors: Alexandra L Tse, Cory M Acreman, Inna Ricardo-Lax, Jacob Berrigan, Gorka Lasso, Toheeb Balogun, Fiona L Kearns, Lorenzo Casalino, Georgia L McClain, Amartya Mudry Chandran, Charlotte Lemeunier, Rommie E Amaro, Charles M Rice, Rohit K Jangra, Jason S McLellan, Kartik Chandran, Emily Happy Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012704

Internet

https://doi.org/10.1371/journal.ppat.1012704

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