Ex vivo osteochondral test system with control over cartilage defect depth – A pilot study to investigate the effect of oxygen tension and chondrocyte based treatments in chondral and full thickness defects in an organ model

Objective: Cartilage defect treatment strategies are dependent on the lesion size and severity. Osteochondral explant models are a platform to test cartilage repair strategies ex vivo. Current models lack in mimicking the variety of clinically relevant defect scenarios. In this controlled laboratory...

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Bibliographic Details
Main Authors: Andrea Schwab, Alexa Buss, Oliver Pullig, Franziska Ehlicke
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913121000364