NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity.

NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity.

The final control of renal water reabsorption occurs in the collecting duct (CD) and relies on regulated expression of aquaporin-2 (AQP2) in principal CD cells. AQP2 transcription is primarily induced by type 2 vasopressin receptor (V2R)-cAMP-protein kinase A (PKA) signaling but also by other factor...

Full description

Bibliographic Details
Main Authors: Eric Féraille, Eva Dizin, Isabelle Roth, Jean-Paul Derouette, Ildiko Szanto, Pierre-Yves Martin, Sophie de Seigneux, Udo Hasler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3900718?pdf=render

Internet

http://europepmc.org/articles/PMC3900718?pdf=render

Similar Items