Impaired SARS-CoV-2 specific T-cell response in patients with severe COVID-19

Impaired SARS-CoV-2 specific T-cell response in patients with severe COVID-19

Cellular immune responses are of pivotal importance to understand SARS-CoV-2 pathogenicity. Using an enzyme-linked immunosorbent spot (ELISpot) interferon-γ release assay with wild-type spike, membrane and nucleocapsid peptide pools, we longitudinally characterized functional SARS-CoV-2 specific T-c...

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Bibliographic Details
Main Authors: Lidewij W. Rümke, Wouter L. Smit, Ailko Bossink, Gijs J. M. Limonard, Danya Muilwijk, Lenneke E. M. Haas, Chantal Reusken, Sanne van der Wal, Bing J. Thio, Yvonne M. G. van Os, Hendrik Gremmels, Jeffrey M. Beekman, Monique Nijhuis, Annemarie M. J. Wensing, Michiel Heron, Steven F. T. Thijsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
COVID-19 ELISpot IFN-γ release assay
T-cell immunity
spike protein
nucleocapsid protein
membrane protein
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1046639/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1046639/full

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