Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

BackgroundDysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA). Citrullination is induced by immune cell-derived peptidyl-Arg deiminases (PADs), which are overactivated in the...

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Bibliographic Details
Main Authors: Myriam Martin, Sara C. Nilsson, David Eikrem, Karin Fromell, Carsten Scavenius, Leonie M. Vogt, Ewa Bielecka, Jan Potempa, Jan J. Enghild, Bo Nilsson, Kristina N. Ekdahl, Meliha C. Kapetanovic, Anna M. Blom
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
citrullination
C1-inhibitor
complement system
PAD
rheumatoid arthritis
synovial fluid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1203506/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1203506/full

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