Role of Protein Kinase C in Metabolic Regulation of Coronary Endothelial Small Conductance Calcium‐Activated Potassium Channels

Role of Protein Kinase C in Metabolic Regulation of Coronary Endothelial Small Conductance Calcium‐Activated Potassium Channels

Background Small conductance calcium‐activated potassium (SK) channels are largely responsible for endothelium‐dependent coronary arteriolar relaxation. Endothelial SK channels are downregulated by the reduced form of nicotinamide adenine dinucleotide (NADH), which is increased in the setting of dia...

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Bibliographic Details
Main Authors: Hang Xing, Sharif A. Sabe, Guangbin Shi, Dwight D. Harris, Yuhong Liu, Frank W. Sellke, Jun Feng
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
calcium‐activated potassium channels
endothelial function
endothelium‐derived hyperpolarization
protein kinase C
reduced nicotinamide adenine dinucleotide
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.031028

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.123.031028

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