Contingencies of UTX/KDM6A Action in Urothelial Carcinoma

Contingencies of UTX/KDM6A Action in Urothelial Carcinoma

The histone demethylase Ubiquitously Transcribed Tetratricopeptide Repeat Protein X-Linked (UTX/KDM6A) demethylates H3K27me2/3 at genes and enhancers and is often inactivated by mutations in urothelial carcinoma (UC). The consequences of its inactivation are however poorly understood. We have invest...

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Bibliographic Details
Main Authors: Alexander Lang, Merve Yilmaz, Christiane Hader, Sammy Murday, Xenia Kunz, Nicholas Wagner, Constanze Wiek, Patrick Petzsch, Karl Köhrer, Julian Koch, Michéle J. Hoffmann, Annemarie Greife, Wolfgang A. Schulz
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
bladder cancer
chromatin regulator
histone demethylase
histone methylation
COMPASS complex
RNA-sequencing
nuclear localization
UTX
MLL
Online Access:https://www.mdpi.com/2072-6694/11/4/481

Internet

https://www.mdpi.com/2072-6694/11/4/481

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