Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy

Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy

Liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS) is a widely utilized technique for in vivo pharmaceutical analysis. Ionization interference within electrospray ion source, occurring between drugs and metabolites, can lead to signal variations, potentially compromis...

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Bibliographic Details
Main Authors: Fulin Jiang, Jingyu Liu, Yagang Li, Zihan Lu, Qian Liu, Yunhui Xing, Janshon Zhu, Min Huang, Guoping Zhong
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS)
Drugs
Metabolites
Ionization interference
Quantitative analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177924000510

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http://www.sciencedirect.com/science/article/pii/S2095177924000510

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