Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis.

Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis.

The tubule-interstitial fibrosis is the hallmark of progressive renal disease and is strongly associated with inflammation of this compartment. Heme-oxygenase-1 (HO-1) is a cytoprotective molecule that has been shown to be beneficial in various models of renal injury. However, the role of HO-1 in re...

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Bibliographic Details
Main Authors: Matheus Correa-Costa, Patricia Semedo, Ana Paula F S Monteiro, Reinaldo C Silva, Rafael L Pereira, Giselle M Gonçalves, Georgia Daniela Marcusso Marques, Marcos A Cenedeze, Ana C G Faleiros, Alexandre C Keller, Maria H M Shimizu, Antônio C Seguro, Marlene A Reis, Alvaro Pacheco-Silva, Niels O S Câmara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3001459?pdf=render

Internet

http://europepmc.org/articles/PMC3001459?pdf=render

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