Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

Transmembrane O-methyltransferase (TOMT/LRTOMT) is responsible for non-syndromic deafness DFNB63. However, the specific defects that lead to hearing loss have not been described. Using a zebrafish model of DFNB63, we show that the auditory and vestibular phenotypes are due to a lack of mechanotransd...

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Bibliographic Details
Main Authors: Timothy Erickson, Clive P Morgan, Jennifer Olt, Katherine Hardy, Elisabeth Busch-Nentwich, Reo Maeda, Rachel Clemens, Jocelyn F Krey, Alex Nechiporuk, Peter G Barr-Gillespie, Walter Marcotti, Teresa Nicolson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
hair cells
mechanotransduction
transmembrane channel-like proteins
tomt
deafness
zebrafish
Online Access:https://elifesciences.org/articles/28474

Internet

https://elifesciences.org/articles/28474

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